91精品香蕉久久,黄色电影视频一区二区

Release date：2020-12-11

Allergy

[IF:6.771]

Dysregulated skin barrier function in Tmem79 mutant mice promotes IL-17A-dependent spontaneous skin and lung inflammation
DOI: 10.1111/all.14488
Abstract:
Background: Atopic dermatitis (AD) is associated with a dysregulation of the skin barrier and may predispose to the development of secondary allergic conditions, such as asthma. Tmem79ma/ma mice harbor a mutation in the gene encoding Transmembrane Protein 79 (or Mattrin), which has previously been associated with AD. As a result of the Tmem79 gene mutation, these mice have a defective skin barrier and develop spontaneous skin inflammation. In this study, Tmem79ma/ma mice were assessed for the underlying immunological response in the development of spontaneous skin and lung inflammation
.Methods: Development of spontaneous skin and lung inflammation in Tmem79ma/ma mice was analyzed. We further investigated susceptibility to cutaneous Staphylococcus aureus infection. Tmem79ma/ma were crossed to IL-17A-deficient mice to address the contribution of IL-17A to spontaneous skin and lung disease.
Results: Tmem79ma/ma mice developed IL-17A-dependent spontaneous AD-like inflammation and were refractory to S aureus infection. Mutant mice progressed to airway inflammation subsequent to the occurrence of dermatitis. The progression from skin to lung disease is dependent on adaptive immunity and is facilitated by cutaneous expansion of Th17 and TCRγδ T cells.
Conclusion: Mice lacking Tmem79/Mattrin expression have a defective skin barrier. In adulthood, these mice develop dermatitis with secondary progression to lung inflammation. The development of skin and lung inflammation is IL-17A-dependent and mediated by TCRγδ T cells
First Author:
Sean P. Saunders
Correspondence:
Padraic Fallon, School of Medicine, Trinity College Dublin, Dublin 2, Ireland.
All Authors:
Sean P. Saunders, Achilleas Floudas, Tara Moran, Ciara M. Byrne, Michael D. Rooney, Caoimhe M. R. Fahy, Joan A. Geoghegan, Yoichiro Iwakura, Padraic G. Fallon, Christian Schwartz
2020-12-11 Article

Hangzhou Zheda Dixun Biological Gene Engineering Co., Ltd. Copyright HZKC Technical support 浙ICP備14005341號（浙）-非經(jīng)營性-2019-0050

Address: Rm.201-209, Bldg.2, No.568 Binkang Rd., Binjiang Dist. Tel: 0571-87968248-805 Website:carnationgroup.cn

Official WeChat

日韩成人av免费电影,久久精品这里只有精品,午夜激情黄色大片网站,亚洲高清一区二区三区不卡av,国产精品久久久一级二级,天天干天天日天天操,国精品无码人妻一区二区三区,综合久久综合久久

杭州浙大迪迅生物基因工程有限公司

Release date：2020-12-11

日韩成人av免费电影,久久精品这里只有精品,午夜激情黄色大片网站,亚洲高清一区二区三区不卡av,国产精品久久久一级二级,天天干天天日天天操,国精品无码人妻一区二区三区,综合 久久 综合 久久

杭州浙大迪迅生物基因工程有限公司

Release date：2020-12-11

日韩成人av免费电影,久久精品这里只有精品,午夜激情黄色大片网站,亚洲高清一区二区三区不卡av,国产精品久久久一级二级,天天干天天日天天操,国精品无码人妻一区二区三区,综合久久综合久久